Antidepressants , Antipsychotics and Anxiolytics

Volume 1

Volume 2

3. Anxiety

3.1 Introduction and Basic Aspects

3.1.5 Neurobiology of anxiety (I) Panic disorder , posttraumatic stress disorder , social phobia and obsessive-compulsive disorder

• พยายาม clarify - connection brain-behavior

3.1.5.1 Posttraumatic stress disorder

• severe, complex disorder

• exposure กับ stressful events

• Symptoms of PTSD - 3 clusters - ตาม Hageman 2001

1. reexperience/intrusion บุกรุก (flashbacks ย้อนหลัง , intrusive recollections , recurrent distressing dreams)

2. avoidance/numbing มึนงง - avoiding thoughts , feelings , activities , และ stimuli in general of traumatic events

3. ลดการ responsiveness to external world

4. marked reduce - feel emotions ~ emotional anaesthesia

5. Hyperarousal - anxiety , sleeping problems

6. exaggerate เกินจริง startle ตกใจ response

7. irritability , angle

3.1.5.2 Panic disorder

• sudden episodes - uncontrollable anxiety ทั้ง cognitive , physiological

• fear and/or - expectancy panic attack

3.1.5.2.1 Neurochemistry

3.1.5.2.2 Noradrenergic system

3.1.5.2.3 Serotonin system

3.1.5.2.5 GABA-Benzodiazepine system

• quantitative most important inh neurotransmitter in CNS

• 1/3 ของ CNS neuro ผ่านทาง GABAergic

• มี 3 receptor subtype

• GABAa

• GABAb

• GABAc

3.2 Clinics

Reference

1. OPDF Antidepressants , Antipsychotics and Anxiolytics