Antidepressants , Antipsychotics and Anxiolytics

Volume 1

Volume 2


3. Anxiety


3.1 Introduction and Basic Aspects


3.1.5 Neurobiology of anxiety (I) Panic disorder , posttraumatic stress disorder , social phobia and obsessive-compulsive disorder
  • พยายาม clarify - connection brain-behavior

3.1.5.1 Posttraumatic stress disorder
  • severe, complex disorder

  • exposure กับ stressful events

  • Symptoms of PTSD - 3 clusters - ตาม Hageman 2001

  1. reexperience/intrusion บุกรุก (flashbacks ย้อนหลัง , intrusive recollections , recurrent distressing dreams)

  2. avoidance/numbing มึนงง - avoiding thoughts , feelings , activities , และ stimuli in general of traumatic events

  3. ลดการ responsiveness to external world

  4. marked reduce - feel emotions ~ emotional anaesthesia

  5. Hyperarousal - anxiety , sleeping problems

  6. exaggerate เกินจริง startle ตกใจ response

  7. irritability , angle

3.1.5.2 Panic disorder
  • sudden episodes - uncontrollable anxiety ทั้ง cognitive , physiological

  • fear and/or - expectancy panic attack


3.1.5.2.1 Neurochemistry
3.1.5.2.2 Noradrenergic system
3.1.5.2.3 Serotonin system

3.1.5.2.5 GABA-Benzodiazepine system
  • quantitative most important inh neurotransmitter in CNS

  • 1/3 ของ CNS neuro ผ่านทาง GABAergic

  • มี 3 receptor subtype

  • GABAa

  • GABAb

  • GABAc


3.2 Clinics

Reference

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